Zogulitsa

(3aR,7aR)-4-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1-piperazin]-2-ium4-methylbenzenesulfonate, yomwe imatchedwanso BISO, ndi mankhwala okhala ndi Kapangidwe kake kapadera kamene kamathandiza kangapo kugwiritsiridwa ntchito kwa chemistry yamankhwala ndi chitukuko cha mankhwala.Mmodzi yemwe angathe kugwiritsa ntchito BISO ndi pochiza matenda a minyewa.Kukhalapo kwa benzo[d]isothiazol-3-yl moiety mu kapangidwe kake kumasonyeza kuti BISO ikhoza kukhala ndi kugwirizana ndi machitidwe apadera a ubongo mu ubongo, monga glutamate kapena GABAergic systems.Ma neurotransmitter awa amakhudzidwa ndi zovuta zambiri zamanjenje monga khunyu, nkhawa, komanso kusokonezeka kwamalingaliro.Ofufuza atha kuwona zomwe BISO ingathe kusinthira machitidwewa ndikupanga zida zatsopano zochizira minyewa. Kuphatikiza apo, BISO's spiro[isoindole-2,1-piperazin] core structure imatha kugwiritsidwa ntchito popanga mankhwala omwe amayang'ana mitundu yosiyanasiyana yamankhwala. Zolinga zachilengedwe.Mawonekedwe ake amitundu itatu komanso kukhalapo kwa magulu ogwira ntchito kumatha kuyanjana ndi ma receptor kapena ma enzymes, kulola kupanga mankhwala osankha komanso amphamvu.Ochita kafukufuku angagwiritse ntchito izi kuti apange mamolekyu ang'onoang'ono omwe amayang'ana zolandilira zomwe zimakhudzidwa ndi matenda osiyanasiyana, monga khansara, matenda a mtima, kapena matenda opatsirana.Kuphatikiza apo, BISO's spirocyclic structure ndi gulu la ammonium lolipiridwa limapangitsa kukhala woyenera pa machitidwe operekera mankhwala.Kukhalapo kwa gulu loyimbidwa kumapangitsa kuti pakhale ma ionic complexes okhala ndi mamolekyu owopsa, monga ma nucleic acid kapena mapuloteni.Mafakitalewa amatha kuthandizira kuperekedwa kwa mamolekyu a bioactive m'maselo enaake kapena minyewa, kupititsa patsogolo chithandizo chamankhwala ndikuchepetsa zotsatira zoyipa zomwe zingachitike. Ndikoyenera kudziwa kuti zomwe BISO zitha kugwiritsidwa ntchito ndizongopeka ndipo zimafunikira kafukufuku ndi chitukuko.Kapangidwe kake kapadera kamapereka mwayi kwa akatswiri azamankhwala kuti afufuze momwe angagwiritsire ntchito mankhwala ndikuwonjezera kuthekera kwake pakupezeka kwa mankhwala.Monga momwe zimakhalira ndi mankhwala aliwonse, kugwiritsa ntchito BISO kuyenera kutsatira ndondomeko ndi malangizo otetezedwa.Ochita kafukufuku ayenera kusamala panthawi ya kaphatikizidwe, kagwiridwe, ndi kasungidwe kake kuti atsimikizire chitetezo ndi kuchepetsa ngozi. ]-2-ium4-methylbenzenesulfonate, kapena BISO, ali ndi lonjezo la ntchito zosiyanasiyana za chemistry yamankhwala ndi chitukuko cha mankhwala.Kapangidwe kake kapadera kamapereka mwayi wopezeka kwa othandizira atsopano, njira zoperekera mankhwala zomwe zimayang'aniridwa, komanso kusinthasintha kwa machitidwe a neurotransmitter.Komabe, kafukufuku wambiri ndi wofunikira kuti afotokoze bwino momwe angagwiritsire ntchito komanso kukulitsa ntchito yake muzamankhwala.