Zogulitsa

3-tert-Butoxycarbonylphenylboronic acid, yomwe imadziwikanso kuti Boc-phenylboronic acid, ndi yofunika kwambiri yochokera ku boronic acid yomwe imagwira ntchito kwambiri mu organic synthesis komanso chemistry yamankhwala. kaphatikizidwe.Gulu la tert-butyloxycarbonyl (BOC) nthawi zambiri limagwiritsidwa ntchito kuteteza kwakanthawi magulu ogwira ntchito amine panthawi zosiyanasiyana.Pogwiritsa ntchito gulu la BOC ku amine moiety, reactivity ya amine imachepetsedwa, zomwe zimapangitsa kuti pakhale zosankha zina pa molekyulu.Gulu la BOC likhoza kuchotsedwa mosavuta pansi pazikhalidwe zofatsa, motero kuwulula ntchito yoyambirira ya amine.Njira yotetezera gululi imathandizira kaphatikizidwe koyenera ka mamolekyu ovuta a organic, monga mankhwala ndi zinthu zachilengedwe.Kuwonjezera apo, 3-tert-Butoxycarbonylphenylboronic acid imakhala ngati reagent yamtengo wapatali yopanga ma carbon-carbon bond.Boronic acids, kuphatikizapo Boc-phenylboronic acid, amapanga boronate esters mosavuta akamakhudzidwa ndi ma nucleophiles, monga mowa kapena amines.Ma esters a boronate awa amatha kusintha mosiyanasiyana, kuphatikiza machitidwe ophatikizika a Suzuki-Miyaura, kulumikizana kwa Negishi, ndi kuphatikiza kwa Stille.Zochita izi zimathandiza kupanga mamolekyu ovuta kwambiri okhala ndi njira zosiyanasiyana zosinthira ndi magulu ogwira ntchito.Boc-phenylboronic acid ndiwothandiza makamaka poyambitsa gawo la phenylboronic acid mu mamolekyu omwe mukufuna. Kuphatikiza apo, asidi a Boc-phenylboronic amagwira ntchito yofunika kwambiri pamankhwala azamankhwala.Magwiridwe a asidi a boronic amatha kuyanjana ndi ma diol kapena magulu okhudzidwa ndi ester-sensitive muzolinga zachilengedwe, zomwe zimathandizira kupanga ma enzyme inhibitors opangidwa ndi boronate ndi ma receptor ligands.Boc-phenylboronic acid imatha kuphatikizidwa muzoletsa mamolekyu ang'onoang'ono, ma peptides, kapena mankhwala opangira kuti apereke zinthu zomwe mukufuna kapena kukulitsa zomwe mukufuna.Mankhwala opangidwa ndi boronate awa asonyeza lonjezano pochiza matenda osiyanasiyana, kuphatikizapo khansa, shuga, ndi kutupa.Mwachidule, 3-tert-Butoxycarbonylphenylboronic acid, kapena Boc-phenylboronic acid, amapeza ntchito zosiyanasiyana mu organic synthesis ndi chemistry yamankhwala.Gulu lake la BOC limagwira ntchito ngati gulu loteteza, lolola kuti pakhale zosankha zina pa molekyulu.Kuphatikiza apo, ntchito ya boronic acid imathandizira kupanga mapangidwe a carbon-carbon bond, kumathandizira kaphatikizidwe ka mamolekyu ovuta.Kuphatikiza apo, Boc-phenylboronic acid imagwira ntchito yofunika kwambiri pamankhwala azamankhwala, komwe imagwiritsidwa ntchito popanga ma enzyme inhibitors a boronate ndi ma receptor ligands.Ponseponse, Boc-phenylboronic acid ndi reagent yofunikira yomwe imathandizira kupita patsogolo kwa chemistry yopanga komanso kafukufuku wopeza mankhwala.