Zogulitsa

3-(3-iodopropyl) -7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one ndi organic compound yovuta yomwe ingagwiritsidwe ntchito mu chemistry yamankhwala ndi kupeza mankhwala.Pagululi lili ndi kapangidwe kake kapadera kamankhwala komwe kamapangitsa kukhala kofunikira pakupanga mankhwala atsopano omwe akutsata njira zenizeni zachilengedwe. Chimodzi mwazinthu zomwe zingagwiritsidwe ntchito pagululi ndi kuthekera kwake kolumikizana ndi zolinga zosiyanasiyana zamoyo.Kukhalapo kwa benzazepinone scaffold mu kapangidwe kake kumapangitsa kuti ikhale yofanana ndi ma neurotransmitters ndi zolandilira.Kufanana kumeneku kumatsegula mwayi woti chigawocho chigwiritsidwe ntchito ngati poyambira pakupanga mankhwala omwe amayang'ana zolandilira m'katikati mwa mitsempha.Posintha kapangidwe ka kaphatikizidwe kameneka, ofufuza amatha kupanga zotumphukira zomwe zikuwonetsa kumangiriza kwa ma receptor enieni, zomwe zitha kupangitsa kuti pakhale njira zatsopano zochizira matenda monga Parkinson's disease, schizophrenia, ndi matenda ena amitsempha. Komanso, 3- (3-iodopropyl) ) -7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one ndipo zotuluka zake zasonyeza kuthekera ngati mankhwala oletsa khansa.Kapangidwe kake kapadera ka mankhwalawa kamathandiza kuti azilumikizana ndi ma cell a khansa, kusokoneza kukula kwawo komanso kufalikira kwawo.Maphunziro oyambirira asonyeza mphamvu zake zolimbana ndi mitundu yosiyanasiyana ya maselo a khansa, zomwe zimapangitsa kuti akhale wodalirika kuti apitirize kufufuza ndi chitukuko monga mankhwala oletsa khansa.Kuphatikiza ndi kuthekera kwake mu chemistry yamankhwala, mankhwalawa angagwiritsidwe ntchito ngati chida chofufuzira mu maphunziro a neuroscience.Kufanana kwake ndi ma neurotransmitters ena amalola kuti azitha kusintha machitidwe a neuronal ndi ntchito yolandirira.Katunduyu amapangitsa kukhala chida chofunikira powerengera njira zamatenda a neurodegenerative ndi matenda amisala.Pofufuza zotsatira za pawiri pa mitsempha ya mitsempha ndi zizindikiro, ochita kafukufuku amatha kudziwa zambiri za njira zomwe zimayambitsa matendawa ndikutha kuzindikira njira zatsopano zochiritsira. -2H-3-benzazepin-2-one imakhala ndi lonjezo lalikulu pazamankhwala azamankhwala ndi sayansi ya ubongo.Kapangidwe kake kapadera ka mankhwala amalola kuphatikizika kwa zotumphukira zomwe zili ndi zida zomangirira zolandilira, zomwe zimapangitsa kukhala chida chamtengo wapatali chopezera mankhwala.Kuphatikiza apo, kuthekera kwake ngati wothandizirana ndi khansa komanso momwe amagwiritsidwira ntchito mu kafukufuku wa sayansi ya ubongo kumawonetsa kusinthasintha kwake pothandizira kupita patsogolo kwa sayansi ndi chitukuko chamankhwala atsopano.Kufufuza kopitilira muyeso ndikuwunika kwapawiriku kungapangitse kuti pakhale chitukuko chachikulu chamankhwala ndi neuroscience.