Zogulitsa

Pawiri (2S,3R,4S,5S,6R) -2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxymethyl)-2 -methoxy-2H-pyran-3,4,5-triol ndi molekyulu yovuta kwambiri yomwe ingagwiritsidwe ntchito m'madera osiyanasiyana, kuphatikizapo mankhwala ndi mankhwala a chemistry. ndi mphete ina ya pirani.Kukhalapo kwa ma stereocenters angapo m'mapangidwe ake kumapangitsa kukhala molekyu ya chiral, kutanthauza kuti ilipo mu mitundu iwiri ya enantiomeric yomwe ingakhale ndi zochitika zosiyana zamoyo.Mapangidwe a molekyulu, monga magulu a benzyl ndi chlorophenyl, kuphatikiza kukhalapo kwa magulu angapo a hydroxyl, akuwonetsa kuti ikhoza kuwonetsa zochitika zachilengedwe.Akatswiri a zamankhwala amatha kufufuza zomwe zingatheke pamagulu monga kutsogolera kwa mankhwala atsopano, makamaka omwe akutsata matenda okhudzana ndi kagayidwe kachakudya. ndi ma receptor kapena ma enzyme omwe amakhudzidwa ndi kagayidwe kachakudya kapena njira zowonetsera.Ochita kafukufuku amatha kufufuza zomwe zimatha kukhala ngati choletsa kapena modulitsa ma enzyme kapena ma receptor omwe amakhudzidwa ndi izi.Kuonjezera apo, kusokonezeka kwapangidwe kapangidwe kameneka kungapangitse kuti akhale woyenera kukhathamiritsa kwa mankhwala a chemistry kudzera muzosintha zamagulu.Magulu a Hydroxyl amatha kutenga nawo gawo pazolumikizana za hydrogen, zomwe zimakhudza kusungunuka kwapawiri, kukhazikika, ndi katundu wa pharmacokinetic.Akatswiri azamankhwala amatha kugwiritsa ntchito maguluwa kuti apititse patsogolo mphamvu zapawiri, kusankha bwino, ndi zinthu zina zamankhwala. Kuvuta kwa kaphatikizidwe kakapangidwe kazachilengedwe kukuwonetsanso zomwe zitha kugwiritsidwa ntchito mu sayansi yazinthu ndi kaphatikizidwe ka organic.Mapangidwe ake apadera amagulu ogwira ntchito atha kugwiritsidwa ntchito popanga ma organic compounds omwe ali ndi zinthu zinazake kapena magwiridwe antchito.Kuphatikiza apo, chigawochi chikhoza kukhala poyambira pakupanga zinthu zatsopano, monga ma polima kapena ma supramolecular, omwe angagwiritsidwe ntchito m'mafakitale osiyanasiyana. Pomaliza, pawiri (2S,3R,4S,5S,6R) -2- (3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxymethyl)-2-methoxy-2H-pyran-3,4,5-triol ali ndi structural zinthu zomwe zimapangitsa kuti zikhale zothandiza mu chemistry yamankhwala ndi zamankhwala, sayansi yazinthu, ndi kaphatikizidwe ka organic.Kapangidwe kake kovutirapo komanso magulu osiyanasiyana ogwira ntchito amapereka mwayi wowunikira pakupezeka kwamankhwala, kusinthasintha kwa ma enzyme, kakulidwe kazinthu, ndi malo ena ofufuza.