Zogulitsa

2,3-Difluoro-4-ethoxybenzeneboronic acid ndi mankhwala omwe amapeza zothandiza m'magawo angapo a chemistry, makamaka mu organic synthesis ndi chemistry yamankhwala.Ndi mawonekedwe ake apadera ndi reactivity, wakhala nyumba yofunika kwambiri yomanga mamolekyu ovuta a organic ndi mankhwala opangira mankhwala.Imodzi mwazofunikira kwambiri za 2,3-Difluoro-4-ethoxybenzeneboronic acid yagona pakugwiritsa ntchito machitidwe ogwirizanitsa.Kulumikizana kophatikizana, monga Suzuki-Miyaura ndi Buchwald-Hartwig couplings, ndi njira zamphamvu zopangira ma bond carbon-carbon ndi carbon-heteroatom.Muzochita izi, 2,3-Difluoro-4-ethoxybenzeneboronic acid imatha kukhala gawo la boronate ester, pochita ndi ma electrophiles osiyanasiyana (mwachitsanzo, aryl halides, vinyl halides) mothandizidwa ndi zopangira zoyenera.Izi zimathandiza kaphatikizidwe zosiyanasiyana mankhwala ndi biologically yogwira katundu, monga mankhwala wothandizila kapena agrochemicals. Komanso, kukhalapo kwa maatomu fluorine mu 2,3-Difluoro-4-ethoxybenzeneboronic asidi akhoza kupereka zopindulitsa katundu chifukwa mamolekyu.Kulowetsedwa kwa fluorine kumatha kupititsa patsogolo kukhazikika, lipophilicity, ndi mbiri ya pharmacokinetic ya mankhwala opangidwa ndi organic, kuwapangitsa kukhala othandiza kwambiri pamankhwala.Chifukwa chake, kugwiritsa ntchito mwanzeru 2,3-Difluoro-4-ethoxybenzeneboronic acid monga kalambulabwalo mu kaphatikizidwe ka mankhwala ngati mankhwala atha kupereka mwayi wopezeka ku mamolekyu a fluorinated omwe ali ndi ntchito yabwino yachilengedwe komanso zinthu zofunika zakuthupi. ,3-Difluoro-4-ethoxybenzeneboronic acid imapereka kusinthasintha kwina pakupanga ntchito.Ikhoza kuchitidwa ndi nucleophilic substitution reactions, kulola kukhazikitsidwa kwa magulu osiyanasiyana ogwira ntchito pa malo a ethoxy.Izi zimathandizira kutulutsa kwapawiriko kuti zigwirizane ndi zinthu zake pazifukwa zinazake kapena kudziwitsanso mfundo zina zamitundu yosiyanasiyana mu kaphatikizidwe ka library kuti apeze mankhwala. chemistry yamankhwala.Kutenga nawo gawo pamachitidwe ophatikizika, kuphatikiza maatomu a fluorine, ndi kutulutsa kwawo pamalo a ethoxy kumapangitsa kuti ikhale chida chofunikira popanga mitundu yosiyanasiyana yamagulu okhala ndi mankhwala omwe angagwiritsidwe ntchito.Kugwiritsiridwa ntchito kwake kumathandizira kuphatikizika kwa mamolekyu ovuta ndi malaibulale kuti apeze mankhwala osokoneza bongo komanso kumapereka mwayi wopezeka ndi mankhwala opangidwa ndi fluorinated okhala ndi zinthu zabwino.