Zogulitsa

2-Pyrrolidinecarboxamide, 1-(2-chloroacetyl)-, (2S)- ndi mankhwala omwe ali ndi ntchito zosiyanasiyana pamagulu a organic chemistry ndi kafukufuku wamankhwala.Pagululi, lomwe limadziwikanso kuti (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide, limawonetsa zinthu zomwe zimapangitsa kuti zikhale zoyenera kuchitapo kanthu pazamankhwala komanso maphunziro achilengedwe. asidi amide angagwiritsidwe ntchito ngati poyambira zinthu kapena wapakatikati mu kaphatikizidwe mamolekyu ovuta kwambiri.Kapangidwe kake ka chiral, komwe kumatchedwa (2S), kumatanthauza kuti ili ndi dongosolo la mbali zitatu la maatomu lomwe lingakhudze stereochemistry ndi mawonekedwe a zotengera zake.Katunduyu amapangitsa kuti ikhale yamtengo wapatali pakupanga ndi kupanga mankhwala atsopano ndi mankhwala opangira mankhwala.M'makampani opanga mankhwala, (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide yaphunziridwa chifukwa cha kuthekera kwake monga inhibitor ya ma enzymes kapena mapuloteni omwe akukhudzidwa nawo. njira zenizeni zamoyo.Kafukufuku wina adayang'ana pakugwiritsa ntchito kwake ngati choletsa ma proteases ena, omwe ndi ma enzymes omwe amagwira nawo ntchito zosiyanasiyana zathupi.Mwa kusankha kulunjika ndi kuletsa ma proteases, zotsatira zoyenera zachipatala zingatheke.Kuonjezera apo, (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide ikhoza kukhala ngati kalambulabwalo wa kaphatikizidwe ka peptide analogs kapena mimetics.Mamolekyuwa amatha kutsanzira kapangidwe kake ndi ntchito ya ma peptide omwe amapezeka mwachilengedwe, motero amakhudza zomwe timakonda kapena zochitika zinazake.Ma analogi oterowo amatha kukhala ndi mwayi wogwiritsa ntchito popanga mankhwala ochizira matenda osiyanasiyana, kuphatikiza khansa, matenda a metabolic, komanso minyewa.Ndikofunikira kudziwa kuti (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide imagwiritsidwa ntchito kwambiri. mu kafukufuku wa labotale ndipo saloledwa kugwiritsidwa ntchito pachipatala.Njira zochiritsira zomwe zingagwiritsidwe ntchito pagululi zikufufuzidwabe, ndipo kafukufuku wowonjezera akufunika kuti adziwe chitetezo chake ndi mphamvu zake mwa anthu. kafukufuku wamankhwala.Chikhalidwe chake cha chiral komanso kuthekera kolepheretsa michere kapena mapuloteni enaake kumapangitsa kukhala kofunikira pakupanga mankhwala atsopano ndi njira zochiritsira.Ngakhale kugwiritsidwa ntchito kwake mu kafukufuku wa labotale kukuwonetsa kulonjeza, kufufuza kwina ndikofunikira kuti mumvetsetse kuthekera kwake pamagwiritsidwe azachipatala.