Zogulitsa

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone, wotchedwanso CF12, ndi mankhwala pawiri ndi ntchito zosiyanasiyana kafukufuku mankhwala ndi kaphatikizidwe.Imodzi mwa ntchito yaikulu ya CF12 yagona mu udindo wake monga zosunthika chipika chomangira kapena wapakatikati pa kaphatikizidwe wa zinthu zovuta organic.CF12 ili ndi magulu ogwira ntchito monga chloro ndi fluoro substituents, omwe amatha kusinthidwa kuti adziwitse magulu ena omwe amafunidwa kapena kusinthidwa kwamapangidwe.Izi zimathandiza akatswiri a zamankhwala makonda pawiri katundu ndi kumapangitsanso ake pharmacological makhalidwe enieni applications.CF12 wasonyeza kuthekera pa chitukuko cha ofuna mankhwala osiyanasiyana madera achire.Mwachitsanzo, kukhalapo kwa chloro ndi fluoro m'malo CF12 akhoza kuonjezera lipophilicity wa pawiri, amene angathe kumapangitsanso mphamvu yake kudutsa nembanemba kwachilengedwenso ndi kusintha mayamwidwe mankhwala.Katunduyu ndi wofunikira kwambiri pamapangidwe amankhwala operekedwa pakamwa. Kuphatikiza apo, mawonekedwe a CF12 amapangitsa kuti ikhale yosangalatsa pofufuza kuthekera kwake ngati antimicrobial agent.Kuphatikiza kwa halogen m'malo mwa halogen kwawonetsedwa kuti kumawonetsa antimicrobial zochita zolimbana ndi mitundu yosiyanasiyana ya mabakiteriya ndi mafangasi.Izi zimatsegula mwayi woti CF12 ifufuzidwe pakupanga maantibayotiki atsopano kapena mankhwala oletsa tizilombo toyambitsa matenda. Kuphatikiza apo, CF12 yapezeka kuti ili ndi zochitika zina zamoyo zomwe zimapangitsa kuti ikhale yoyenera pazamankhwala ena.Kafukufuku wasonyeza kuti CF12 limasonyeza kwambiri odana ndi kutupa katundu, mwina kuzipanga kukhala zofunika zochizira matenda yodziwika ndi kutupa, monga matenda autoimmune kapena matenda yotupa matenda. kafukufuku ndi chitukuko zikufunika kuti mumvetse bwino zomwe zingatheke ngati ofuna mankhwala.Maphunziro ochulukirapo a preclinical, kuphatikiza kuyesa kwa in vitro ndi mu vivo, ndikofunikira kuti muwone ngati CF12 ikugwira ntchito, mawonekedwe a pharmacokinetic, komanso mbiri yachitetezo.Komanso, kukhathamiritsa kwa kapangidwe ka mankhwala a CF12 ndi kufufuza ntchito yake motsutsana ndi mipherezero yeniyeni ya matenda ndikofunikira kuti mutsegule mphamvu zake zonse. Mwachidule, (2-Chloro-5-iodophenyl) (4-fluorophenyl) methanone (CF12) ali ndi chiyembekezo cha kafukufuku wamankhwala ndi kaphatikizidwe.Kugwiritsiridwa ntchito kwake monga nyumba yomangira kumapangitsa kuti pakhale zovuta zowonongeka, pamene mawonekedwe ake a pharmacological monga lipophilicity ndi antimicrobial ntchito amachititsa kuti akhale woyenera pa chitukuko cha mankhwala m'madera monga antibiotics, antifungals, ndi anti-inflammatory agents.Komabe, kafukufuku wochulukirapo akufunikabe kuti awunike mokwanira momwe angachiritsire komanso kudziwa momwe angagwiritsire ntchito mankhwala.