Zogulitsa

Pawiri 2-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1, 3 (2H) -dione ndi molekyu yovuta kwambiri yomwe ingagwiritsidwe ntchito m'madera a mankhwala ndi mankhwala.Kupezeka kwa isoindole pachimake kumasonyeza kuti pawiriyi ili ndi mawonekedwe opangidwa ndi biologically ndipo apezeka mu mamolekyu a bioactive.Zomwe zimachokera ku Isoindole zakhala zikudziwika kuti zimakhala ndi mankhwala osiyanasiyana, kuphatikizapo antitumor, anti-inflammatory, and antimicrobial activities.The oxazolidinone moiety, yomwe imayimiridwa ndi gulu la 1,3-oxazolidin-5-yl, imadziwika ndi ntchito yake yoletsa antibacterial.Oxazolidinone akhala akugwiritsidwa ntchito ngati zigawo zofunika kwambiri za maantibayotiki, makamaka motsutsana ndi mabakiteriya osamva mankhwala.Izi zikusonyeza kuti chigawocho chikhoza kukhala ndi mphamvu ngati antibacterial agent.Kupezeka kwa moiety ya morpholinone, yomwe imayimiridwa ndi gulu la 4-(3-oxomorpholin-4-yl) phenyl, imawonjezera zovuta zina zomwe zimagwiritsidwa ntchito pamagulu.Ma Morpholines adaphatikizidwa kwambiri muzinthu zamankhwala chifukwa cha kuthekera kwawo kolumikizana ndi zolinga zosiyanasiyana zamoyo.Gulu la oxo pa morpholinone likhoza kupititsa patsogolo kuyanjana kwa mankhwalawa ndi zolinga zenizeni, zomwe zimapangitsa kuti zikhale zomangira zofunikira pakupeza mankhwala ndi chitukuko. Gulu la 1,3-oxazolidin-5-yl, lomwe limaphatikizidwa pachimake cha isoindole, limapanga malo akuluakulu ogwira ntchito pamagulu.Mapangidwe apadera a mankhwala a gululi amasonyeza kuti akhoza kukhala ndi kugwirizana ndi zolinga zamoyo monga ma enzymes kapena receptors.Ponseponse, potengera mawonekedwe a pawiri, ali ndi mphamvu zowonetsera ntchito za pharmacological mu antibacterial, anti-inflammatory, ndi madera ena omwe angakhale ochiritsira.Komabe, ntchito zake zenizeni ndi njira zogwirira ntchito ziyenera kutsimikiziridwa kudzera mu maphunziro owonjezera, kuphatikizapo kuyesa kwa in vitro ndi mu vivo, kuti awone momwe ntchito yake ikuyendera komanso mbiri ya chitetezo. -3--[4-(3-oxomorpholin-4-yl) phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione amasonyeza lonjezo m'madera a mankhwala ndi mankhwala chifukwa cha mawonekedwe ake ovuta komanso kuthekera kwamankhwala.Kafukufuku wamtsogolo ndi wofunikira kuti afufuze momwe angagwiritsire ntchito, momwe angagwiritsire ntchito mankhwala, komanso mphamvu zake zonse.