Zogulitsa

(1R,2S,5S)—6,6-DiMethyl-3-aza-bicylo[3.1.0]hexane-2-carboxylic acid Methyl ester hydrochloride ndi mankhwala omwe ali ndi ntchito zosiyanasiyana pa kafukufuku wamankhwala ndi chitukuko cha mankhwala. Kugwiritsiridwa ntchito kwakukulu kwa mankhwalawa ndi monga chopangira chiral mu kaphatikizidwe ka mankhwala ophatikizika ndi mankhwala othandizira mankhwala (APIs).Mapangidwe ake apadera a bicyclic ndi kukongola kwake kumapangitsa kuti ikhale yofunikira popanga zopangira zoyera za enantiomerically.Pophatikizira chigawo ichi mu kaphatikizidwe, akatswiri a zamankhwala amatha kuwongolera stereochemistry ndikupanga zinthu zenizeni zamankhwala m'mamolekyu omwe amabwera.Izi ndizofunikira makamaka pakukula kwa mankhwala, kumene ntchito yofunikira yachilengedwe nthawi zambiri imadalira dongosolo la malo a molekyulu. Kuwonjezera apo, (1R,2S,5S)—6,6-DiMethyl-3-aza-bicylo[3.1.0]hexane -2-carboxylic asidi Methyl ester hydrochloride ntchito ngati kalambulabwalo kwa synthesis wa quinuclidine ofotokoza mankhwala.Zotumphukira za quinuclidine zawonetsa zinthu zambiri zamoyo, kuphatikizapo antipsychotic, anticonvulsant, ndi analgesic properties.Poyambitsa magulu apadera ogwira ntchito kumagulu, akatswiri a zamankhwala amatha kusintha mankhwala ake a pharmacokinetic ndi pharmacodynamic, kupititsa patsogolo mphamvu zake zochiritsira.Chifukwa cha kukhalapo kwa amine yapamwamba komanso kulepheretsa kwamagulu a methyl, imatha kutenga nawo mbali pamachitidwe osiyanasiyana amankhwala, monga amidation, alkylation, ndi cycloaddition reaction.Kuchitanso kwake komanso kutha kupanga zovuta zapakati zimapangitsa kukhala chida chosunthika mu kaphatikizidwe ka organic, kulola kuti pakhale mitundu yosiyanasiyana yamagulu.Mwachidule, (1R,2S,5S)—6,6-DiMethyl-3-aza-bicylo[3.1 .0]hexane-2-carboxylic acid Methyl ester hydrochloride ndi yofunika kwambiri pakupanga mankhwala ndi kaphatikizidwe ka organic.Chirality ndi dongosolo lapadera zimathandiza kupanga enantiomerically koyera mankhwala ndi synthesis quinuclidine ofotokoza mankhwala ndi enieni pharmacological katundu.Reactivity yake imapangitsanso kukhala chothandiza komanso chothandizira pakusintha kwamitundu yosiyanasiyana.Ponseponse, mankhwalawa amathandizira kwambiri kupititsa patsogolo kafukufuku wamankhwala komanso kupanga othandizira atsopano.