Zogulitsa

M'badwo wachiwiri platinamu zovuta antineoplastic mankhwala.Antitumor spectrum ndi antitumor ntchito ndizofanana ndi za cisplatin, koma kusungunuka kwamadzi ndikwabwino kuposa kwa cisplatin, komanso kawopsedwe ka impso nawonso ndi wotsika.Iwo ali wabwino machiritso zimakhudza yaing'ono selo khansa ya m'mapapo, khansa yamchiberekero, mutu ndi khosi squamous cell carcinoma, testicular chotupa, malignant lymphoma, etc. Angagwiritsidwenso ntchito khansa ya khomo lachiberekero, chikhodzodzo khansa, etc.

Mankhwala a anticancer a m'badwo wachiwiri wa platinamu ali ndi ntchito zofanana ndikugwiritsa ntchito cisplatin.Imagwira ntchito kwambiri kuposa cisplatin pa zotupa zina, ndipo ndi yamphamvu kuposa cisplatin ngati radiosensitizer pansi pa hypoxic mikhalidwe.Amagwiritsidwa ntchito makamaka pa khansa ya ovarian, khansa ya testicular, khansa yaing'ono ya m'mapapo ndi khansa ya mutu ndi khosi.

Carboplatin ndi mankhwala oletsa khansa opangidwa ndi platinamu omwe amawononga DNA popanga ma intrachain conjugation ndi zotsalira za guanine.Mphamvu ya antitumor ya mankhwalawa imatheka chifukwa cha kutayika kwa ntchito ya DNA mismatch repair (MMR vaccine) ndikuyambitsa kufa kwa cell.