Zogulitsa

(αS, 3S) -α--[(tert-Butyloxycarbonyl) amino] -2-oxo-3-pyrrolidinepropanoic acid methyl ester, yomwe imadziwikanso kuti Boc-Amino acid methyl ester, ndi yofunika kwambiri pamagulu a organic synthesis ndi peptide. chemistry.Boc-Amino acid methyl ester imakhala ngati mawonekedwe otetezedwa a amino acid, kumene gulu la Boc (tert-butyloxycarbonyl) limagwiritsidwa ntchito kuteteza gulu la amino panthawi ya zochita.Chigawochi chimagwiritsidwa ntchito makamaka popanga peptide poyambitsa ma amino acid enieni mu unyolo wa peptide.Mapeptidi ndi maunyolo afupiafupi a amino acid omwe amagwira ntchito yofunika kwambiri muzinthu zamoyo.Amakhudzidwa ndi njira zosiyanasiyana monga kusaina, kuwongolera ma enzyme, ndi chithandizo chamapangidwe.Kuphatikizika kwa peptide kumaphatikizapo kuphatikizika kwa ma amino acid kuti apange mindandanda yeniyeni yomwe imatsanzira ma peptide achilengedwe kapena kupanga zida zatsopano zokhala ndi katundu wofunidwa. imodzi mwa njira zomwe zimagwiritsidwa ntchito kwambiri popanga ma peptides.Mu SPPS, unyolo wa peptide umapangidwa pang'onopang'ono pa chithandizo cholimba, makamaka pogwiritsa ntchito chochokera ku amino acid ndi gulu loteteza kwakanthawi.Boc-Amino acid methyl ester ndi yabwino kwambiri poyambira SPPS chifukwa cha kukhazikika kwake, kusungunuka, ndi kuyanjana ndi ma peptide synthesis reagents.Pakati pa kaphatikizidwe ka peptide, Boc-Amino acid methyl ester amawonjezeredwa ku unyolo wa peptide womwe ukukula kupyolera mu mapangidwe a amide bond.Gulu loteteza la Boc limalepheretsa zochitika zam'mbali zosafunikira ndikuwonetsetsa kuti amino acid amalumikizana ndi unyolo wa peptide.Kutsatira komwe kumafunidwa kukwaniritsidwa, gulu la Boc limachotsedwa pansi pazikhalidwe zofatsa, kuwulula gulu la amino laulere kuti lisinthidwenso kapena mawonekedwe a peptide. Kuphatikiza pa peptide synthesis, Boc-Amino acid methyl ester ingagwiritsidwenso ntchito popanga mankhwala osiyanasiyana. intermediates, agrochemicals, ndi zina organic mankhwala.Kugwira kwake kosavuta, kukhazikika, komanso kuyanjana ndi zochitika zomwe zimapangidwira zimapangitsa kuti zikhale zosunthika zomangira organic synthesis.Ponseponse, Boc-Amino acid methyl ester ndi chida chamtengo wapatali mu peptide synthesis ndi organic chemistry.Udindo wake ngati mawonekedwe otetezedwa a ma amino acid amalola kugwirizanitsa bwino kwa unyolo wa peptide ndikupanga mitundu yosiyanasiyana ya peptide pofufuza, kupeza mankhwala, komanso kugwiritsa ntchito mankhwala.